Biomarkers Predicting Isocyanate-Induced Asthma
نویسندگان
چکیده
منابع مشابه
Biomarkers Predicting Isocyanate-Induced Asthma
THREE DIISOCYANATES CAN CAUSE OCCUPATIONAL ASTHMA (OA): toluene diisocyanate (TDI), 4,4 diphenylmethane diisocyanate (MDI), and 1,6-hexamethylene diisocyanate (HDI). We analyzed potential biomarkers of isocyanate-induced OA, based on investigated immunologic, genetic, neurogenic, and protein markers, because there is no serological testing method. The prevalence of serum IgG to cytokeratin (CK)...
متن کاملOutcome determinants for isocyanate induced occupational asthma among compensation claimants.
OBJECTIVES To compare the outcome of occupational asthma (OA) induced by isocyanates in Ontario (where a surveillance programme for exposed workers has been in place for over 15 years), with the outcome of OA induced by other work agents. METHODS Compensated OA claims during the period 1984-88 in Ontario were retrospectively reviewed in a standardised way. RESULTS 136/235 compensated claims...
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Isocyanate is the most prevalent agent in occupational asthma(OA) in Korea. We analyzed 43 toluene diisocyanate(TDI) induced OA patients of whom 81% were found to be spray painters. The bronchial sensitivity of all subjects was confirmed by TDI-bronchial challenge test. Serum-specific IgE antibodies to isocyanate-human serum albumin(HSA) conjugate were detected by RAST technique(Pharmacia, Swed...
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Data from Washington State's work-related asthma surveillance system were used to characterize isocyanate-induced asthma cases occurring from 1999 through 2010. Injured worker interviews and medical records were used to describe the industry, job title, work process, workers' compensation cost, and exposure trends associated with 27 cases of isocyanate-induced asthma. The majority (81%) of case...
متن کاملUpdate on the Pathogenic Mechanisms of Isocyanate-induced Asthma
BACKGROUND : The pathogenic mechanisms of toluene diisocyanate (TDI)-induced asthma are not understood clearly. METHODS : In this review, we summarized recent data to further understand the pathogenic mechanisms through recent approach of molecular genetic studies, and specific antibody responses to cellular mechanisms. RESULTS : Genetic polymorphism studies suggested the involvement of oxi...
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ژورنال
عنوان ژورنال: Allergy, Asthma and Immunology Research
سال: 2011
ISSN: 2092-7355
DOI: 10.4168/aair.2011.3.1.21